What is PROsetta Stone?

A common problem when using a variety of Patient-Reported Outcome (PRO) measures is the comparability of scales on which the outcomes are reported. Linking establishes relationships between scores on two different measures.

The PRO Rosetta Stone (PROsetta Stone®) developed and applied methods to link the Patient-Reported Outcomes Measurement Information System (PROMIS) with other related instruments (e.g., SF-36Brief Pain InventoryCES-DMASQFACIT-Fatigue) to expand the range of PRO assessment options within a common, standardized metric. It provides equivalent scores for different scales that measure the same health outcome.  



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The PROsetta Stone® project represents a major step towards clarifying the relationships between instruments that measure similar constructs.


By applying three different linking methods, the PROsetta Stone® methodology places two instruments on the same metric, allowing the creation of a cross-walk table. This cross-walk table matches each possible score on a "legacy" instrument to a T-score of the comparable PROMIS instrument. (The PROMIS T-score has a mean of 50 and a standard deviation of 10, and is centered on the US general population.)  More>>​


Linking Measures to PROMIS

PROsetta Stone® links many instruments to the PROMIS metric. These instruments are widely accepted “legacy” measures that have been used as part of the initial validation work for PROMIS and NIH Toolbox.  

Data were collected on a minimum of 400 respondents (for stable item parameter estimation) along with at least one other conceptually similar scale or bank.  More>>